Tg(CEPHY152F7)57Hgc
Transgene Detail

Summary

• Symbol: Tg(CEPHY152F7)57Hgc
• Name: transgene insertion 57, Edward Rubin
• MGI ID: MGI:5293456
• Synonyms: 152F7, YAC 152F7, YAC 152F7 Line 57, YAC Lg 57
• Transgene: Tg(CEPHY152F7)57Hgc Location: unknown
• Alliance: Tg(CEPHY152F7)57Hgc page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CEPHY152F7)57Hgc expresses 4 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DYRK1A (1859)

  Dyrk1a

  (MGI:1330299)

  human

  KCNJ6 (3763)

  Kcnj6

  (MGI:104781)

  human

  TTC3 (7267)

  Ttc3	(MGI:1276539)

  human

  VPS26C (10311)

  Vps26c

  (MGI:1206040)

• Mutation details: The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 570-kb fragment of DNA from human Chromosome 21 that includes the potassium inwardly-rectifying channel, subfamily J, member 6 gene, KCNJ6 (also called GIRK2, KIR3.2 or HUM21ES123), which is expressed in the brain both in humans and in mice bearing the YAC as a transgene. Line 57 was shown by quantitative PCR analysis to carry two copies of the YAC. (J:128897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
• All: 5 reference(s)