Tg(Gata1*V205G)1Mym
Transgene Detail

Summary

• Symbol: Tg(Gata1*V205G)1Mym
• Name: transgene insertion 1, Masayuki Yamamoto
• MGI ID: MGI:5295641
• Synonyms: V205G
• Transgene: Tg(Gata1*V205G)1Mym Location: unknown
• Alliance: Tg(Gata1*V205G)1Mym page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gata1*V205G)1Mym expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gata1 (MGI:95661)	Transgene codes for a protein with a valine to glycine mutation.

• Mutation details: This transgene consists of the murine Gata1 cDNA with a V205G (GTG to GGG) mutation under the control of the Gata1 genomic locus spanning 3.9 kb 5' of the hematopoietic IE exon to the second exon (GATA-1 HRD) which recapitulates endogenous Gata1 gene expression. The valine 205 to glycine substitution has been shown to reduce Zfpm1 (Fog-1) association. Five lines were made. This line is a high-expressing line. (J:89054)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:89054 Shimizu R, et al., Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia. Blood. 2004 Apr 1;103(7):2560-7
• All: 2 reference(s)