Mirc11 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc11
• Name
  microRNA cluster 11, including Mir23a through Mir24-2

• Feature Type
  complex/cluster/region
• IDs
  MGI:5295773
• Cluster Members
  Mir23a, Mir27a, Mir24-2 ... (4 members)

Location &
Maps

• Sequence Map
  Chr8:84935147-84935550 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, Syntenic

Strain
Comparison

• SNPs within 2kb
  79 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  10 phenotype references
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  1
• Targeted
  4
• Find Mice (IMSR)
  2 strains or lines available

Mice homozygous for a knock-out allele exhibit enhanced B cell lymphogenesis and impaired myelopoiesis.

Other Database
Links

miRBase

MI0000571, MI0000572, MI0000578, MI0014104

References

• Summaries
  All 13

  Phenotypes 10
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:344664 Sprenkle NT, et al., The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue. Cell Rep. 2023 Aug 29;42(8):112928

Mirc11 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir23a, microRNA 23a	miRNA gene	Chr8:84935147-84935221 (+)
Mir27a, microRNA 27a	miRNA gene	Chr8:84935301-84935387 (+)
Mir24-2, microRNA 24-2	miRNA gene	Chr8:84935444-84935550 (+)
Mir3074-2, microRNA 3074-2	miRNA gene	Chr8:84935454-84935536 (-)