Tg(Ggt1-Hif1a*)43Log
Transgene Detail

Summary

• Symbol: Tg(Ggt1-Hif1a*)43Log
• Name: transgene insertion 43, Lorraine J Gudas
• MGI ID: MGI:5298013
• Synonyms: gamma-HIF1alpha-M3, gamma-HIF1alpha-M3-43
• Transgene: Tg(Ggt1-Hif1a*)43Log Location: unknown
• Alliance: Tg(Ggt1-Hif1a*)43Log page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ggt1-Hif1a*)43Log expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HIF1A (3091)

  Hif1a

  (MGI:106918)

• Mutation details: The rat promoter drives kidney proximal tubule-specific expression of the human cDNA with three amino acid substitutions (P402A, P564A, and N803A). Four lines were generated (8, 25, 32, and 43) with similar phenotypes. Line 43 exhibits the strongest phenotype. (J:177381)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:177381 Fu L, et al., Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1alpha. Cancer Res. 2011 Nov 1;71(21):6848-56
• All: 2 reference(s)