Tg(CMV-MYOC*Y437H)#Vcs
Transgene Detail

Summary

• Symbol: Tg(CMV-MYOC*Y437H)#Vcs
• Name: transgene insertion, Val C Sheffield
• MGI ID: MGI:5302242
• Synonyms: Tg(CMV-MYOC^Y437H)/Vcs, Tg-MYOC^Y437H
• Transgene: Tg(CMV-MYOC*Y437H)#Vcs Location: unknown
• Alliance: Tg(CMV-MYOC*Y437H)#Vcs page

Transgene origin

• Strain of Origin: C57BL/6J x SJL/J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-MYOC*Y437H)#Vcs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYOC (4653)

  Myoc	(MGI:1202864)

• Mutation details: This transgene expresses human myocilin containing the Y437H mutation under the control of the CMV promoter. Expression of the mutant protein is seen in the iridocorneal angle and sclera but is absent in the retina, similarly to endogenous Myoc expression. Mutant protein accumulates in the endoplasmic reticulum. (J:178254)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178254 Zode GS, et al., Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clin Invest. 2011 Sep 1;121(9):3542-53
• All: 10 reference(s)