Tg(RP11-209M4*)#Gglo
Transgene Detail

Summary

• Symbol: Tg(RP11-209M4*)#Gglo
• Name: transgene insertion, Gabriela G Loots
• MGI ID: MGI:5304447
• Synonyms: SOST^vbdelta, Tg(RP11-209M4VBD)
• Transgene: Tg(RP11-209M4*)#Gglo Location: unknown
• Alliance: Tg(RP11-209M4*)#Gglo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP11-209M4*)#Gglo expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MEOX1 (4222)

  Meox1

  (MGI:103220)

  human

  SOST (50964)

  Sost	(MGI:1921749)

• Mutation details: The transgene contains human BAC RP11-209M4 in which 52 KB between the 3' end of MEOX1 and SOST are removed. This region is removed in human patients with Van Buchem disease. Three lines were generated (A, B, and an unnamed line). RT-PCR and quantitative PCR confirmed that all lines express human SOST in the mineralized bone of neonatal and adult mice (skull, rib, and femur) and in the adult kidney and heart at a lesser amount than in mice expressing the wild-type BAC. No expression of human Meox was detected. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99965 Loots GG, et al., Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005 Jul;15(7):928-35
• All: 1 reference(s)