Tg(RP11-209M4)AGglo
Transgene Detail

Summary

• Symbol: Tg(RP11-209M4)AGglo
• Name: transgene insertion A, Gabriela G Loots
• MGI ID: MGI:5304449
• Synonyms: SOST TG, SOST^wt, Tg(RP11-209M4)#Gglo
• Transgene: Tg(RP11-209M4)AGglo Location: unknown
• Alliance: Tg(RP11-209M4)AGglo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP11-209M4)AGglo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOST (50964)

  Sost	(MGI:1921749)

• Mutation details: The transgene contains the wild-type human BAC RP11-209M4, which contains SOST and the 3' end of MEOX. RT-PCR and quantitative PCR confirmed that all lines express human SOST in the mineralized bone of neonatal and adult mice (skull, rib, and femur) and in the adult kidney. No expression of human MEOX was detected. Three lines were generated (A, B, and an unnamed line). Founder line A was analyzed for expression. (J:99965)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:99965 Loots GG, et al., Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005 Jul;15(7):928-35
• All: 5 reference(s)