Tg(Acta2-cre/ERT2)#Pcn
Transgene Detail

Summary

• Symbol: Tg(Acta2-cre/ERT2)#Pcn
• Name: transgene insertion, Pierre Chambon
• MGI ID: MGI:5305721
• Synonyms: alphaSMA-Cre-ER^T2, Sma^CreER
• Transgene: Tg(Acta2-cre/ERT2)#Pcn Location: unknown
• Alliance: Tg(Acta2-cre/ERT2)#Pcn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Acta2-cre/ERT2)#Pcn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Acta2 (MGI:87909)

• Mutation details: A construct containing cre fused to ERT2 followed by an frt flanked PGK-neo cassette was inserted at the initiation codon of Acta2 in a 175 kb mouse BAC. Tamoxifen-induced cre activity was seen in smooth muscle cells. (J:144642)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acta2 (mouse) Summary of all recombinase alleles driven by Acta2. Comparative matrix view of recombinase activities Alliance mouse Acta2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144642 Wendling O, et al., Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse. Genesis. 2009 Jan;47(1):14-8
• All: 71 reference(s)