Tg(Lgi1*)#Mpan
Transgene Detail

Summary

• Symbol: Tg(Lgi1*)#Mpan
• Name: transgene insertion, Matthew P Anderson
• MGI ID: MGI:5307228
• Synonyms: mLGI1
• Transgene: Tg(Lgi1*)#Mpan Location: unknown
• Alliance: Tg(Lgi1*)#Mpan page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lgi1*)#Mpan expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lgi1 (MGI:1861691)

• Mutation details: This transgene consists of a hemagglutinin-tagged mouse Lgi1 BAC construct containing a premature translational stop codon in exon 6 to reproduce the human autosomal dominant lateral temporal lobe epilepsy mutation 835delC that truncates the C-terminal epitempin repeat and ADAM22-binding domain. (J:154129)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154129 Zhou YD, et al., Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009 Oct;15(10):1208-14
• All: 3 reference(s)