Tg(ED-L2-IL1RN/IL1B)#Tcw
Transgene Detail

Summary

• Symbol: Tg(ED-L2-IL1RN/IL1B)#Tcw
• Name: transgene insertion, Timothy C Wang
• MGI ID: MGI:5308012
• Synonyms: L2-IL-1Beta
• Transgene: Tg(ED-L2-IL1RN/IL1B)#Tcw Location: unknown
• Alliance: Tg(ED-L2-IL1RN/IL1B)#Tcw page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ED-L2-IL1RN/IL1B)#Tcw expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL1B (3553)

  Il1b	(MGI:96543)

  human

  IL1RN (3557)

  Il1rn

  (MGI:96547)

• Tg(ED-L2-IL1RN/IL1B)#Tcw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Epstein-Barr virus	ED-L2

• Mutation details: The Epstein-Barr virus ED-L2 promoter drives expression of a modified human IL1B cDNA. The modified human IL1B cDNA consists of the IL1RN signal sequence and a cDNA encoding for the 17 kDa mature human IL1B. Two lines were generated one with high expression and one with low expression. (J:180282)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(ED-L2-IL1RN/IL1B)#Tcw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:180282 Quante M, et al., Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia. Cancer Cell. 2012 Jan 17;21(1):36-51
• All: 7 reference(s)