Tg(Thy1-TARDBP*)BOddo
Transgene Detail

Summary

• Symbol: Tg(Thy1-TARDBP*)BOddo
• Name: transgene insertion B, Salvatore Oddo
• MGI ID: MGI:5310969
• Synonyms: TgTDP-25(B)
• Transgene: Tg(Thy1-TARDBP*)BOddo Location: unknown
• Alliance: Tg(Thy1-TARDBP*)BOddo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-TARDBP*)BOddo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: This transgene contains the 25-kDa C-terminal fragment of human TARDBP (encoding the last 199 amino acids) under the control of the Thy1.2 neuron specific regulatory sequence. Transgenic mice exhibit an accumulation of the 25-kDa fragment in the cytosolic fraction. Line B is the high expressing line and real-time PCR indicates 4.71 copies of the transgene in this line. (J:180165)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:180165 Caccamo A, et al., Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43. Am J Pathol. 2012 Jan;180(1):293-302
• All: 2 reference(s)