Mirc14 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc14
• Name
  microRNA cluster 14, including Mir181a-1 through Mir181b-1

• Feature Type
  complex/cluster/region
• IDs
  MGI:5313566
• Cluster Members
  Mir181a-1, Mir181b-1 (2 members)

Location &
Maps

• Sequence Map
  Chr1:137894193-137894456 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, Syntenic

Strain
Comparison

• SNPs within 2kb
  140 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotypes from 5 alleles in 5 genetic backgrounds
  10 phenotypes from multigenic genotypes
  20 phenotype references
  

• All Mutations and Alleles
  6
• Targeted
  6
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased DN3 thymocyte, double-positive T cell, early thymic T cell progenitors, germinal B cells and peripheral B cell numbers, increased latency to Notch-induced leukemia and increased marginal zone B cell number.

Other Database
Links

miRBase

MI0000697, MI0000723

References

• Summaries
  All 21

  Phenotypes 20
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:358629 Costa BLD, et al., Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy. Cell Biosci. 2024 May 21;14(1):64

Mirc14 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir181a-1, microRNA 181a-1	miRNA gene	Chr1:137894193-137894279 (+)
Mir181b-1, microRNA 181b-1	miRNA gene	Chr1:137894377-137894456 (+)