Tg(Myh6-MYL2*A13T)L1Dsc
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYL2*A13T)L1Dsc
• Name: transgene insertion L1, Danuta Szczesna-Cordary
• MGI ID: MGI:5315427
• Synonyms: Tg-A13T
• Transgene: Tg(Myh6-MYL2*A13T)L1Dsc Location: unknown
• Alliance: Tg(Myh6-MYL2*A13T)L1Dsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYL2*A13T)L1Dsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYL2 (4633)

  Myl2	(MGI:97272)

• Mutation details: This transgene expresses the human ventricular myosin regulatory light chain with an A13T mutation under the mouse alpha-myosin heavy chain promoter. (J:181028)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:181028 Kazmierczak K, et al., Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice. Biochem J. 2012 Feb 15;442(1):95-103
• All: 1 reference(s)