Mirc27 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc27
• Name
  microRNA cluster 27, including Mir497 through Mir195a

• Feature Type
  complex/cluster/region
• IDs
  MGI:5315433
• Cluster Members
  Mir497, Mir195a (2 members)

Location &
Maps

• Sequence Map
  Chr11:70125543-70125961 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, Syntenic

Strain
Comparison

• SNPs within 2kb
  34 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 2 alleles in 2 genetic backgrounds
  7 phenotype references
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  2
• Targeted
  3
• Find Mice (IMSR)
  3 strains or lines available

Mice mice homozygous for a conditional allele activated in hematopoietic cells exhibit normal blood and spleen CD5+ B cell numbers, spleen weight, NK cell development, early B-cell development, and immune cell homeostasis and function.

Expression

• Assay Results
  5
• Tissues
  3
• Literature Summary
  1

Images

Tissue x Stage Matrix

Molecular
Reagents

• All nucleic 1

  Primer pair 1

Other Database
Links

miRBase

MI0000237, MI0004636

References

• Summaries
  All 9

  Developmental Gene Expression 1

  Phenotypes 7
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:330835 Hutter K, et al., The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol. 2022;13:967914

Mirc27 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir497, microRNA 497	miRNA gene	Chr11:70125543-70125626 (+)
Mir195a, microRNA 195a	miRNA gene	Chr11:70125868-70125961 (+)