Mirc30 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc30
• Name
  microRNA cluster 30, including Mir16-1 through Mir15a

• Feature Type
  complex/cluster/region
• IDs
  MGI:5315448
• Cluster Members
  Mir16-1, Mir15a (2 members)

Location &
Maps

• Sequence Map
  Chr14:61869329-61869559 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, Syntenic

Strain
Comparison

• SNPs within 2kb
  43 from dbSNP Build 142

Human Diseases

• Diseases
  1 with Mirc30 mouse models

Human Disease

Mouse Models

chronic lymphocytic leukemia

IDs

chronic lymphocytic leukemia      

DOID:1040
EFO:0000095
ICD10CM:C91.10
ICD9CM:204.1
MESH:D015451
NCI:C3163
OMIM:109543
OMIM:151400
OMIM:609630
OMIM:612557
OMIM:612558
OMIM:612559
ORDO:67038
UMLS_CUI:C0023434

View 6 models

Mouse Models

Human Disease Modeled: chronic lymphocytic leukemia

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	J:156946	View
Mirc30tm1.2Rdf/Mirc30tm1.2Rdf	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	J:156946	View
Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf Cd19tm1(cre)Cgn/Cd19+	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	J:179879	View
Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf Cd19tm1(cre)Cgn/Cd19+	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	J:156946	View
Del(14Trim13-Rnaseh2b)6Rdf/+ Cd19tm1(cre)Cgn/Cd19+	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	J:179879	View
Mirc30em1Hhzg/Mirc30em1Hhzg Tg(Vav1-cre)#Cgp/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj	J:320883	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  2 with disease annotations

• References
  3 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 4 alleles in 4 genetic backgrounds
  28 phenotype references
  

• All Mutations and Alleles
  10
• Endonuclease-mediated
  2
• Targeted
  8
• Genomic Mutations
  3 involving Mirc30
• Find Mice (IMSR)
  4 strains or lines available

Mice homozygous for a conditional allele activated in hematopoietic cells exhibit chronic lymphocytic leukemia with increased B cell numbers, increased spleen weight, and a partial block to NK cell development.

Other Database
Links

miRBase

MI0000564, MI0000565

References

• Summaries
  All 29

  Diseases 3

  Phenotypes 28
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:354576 Zhou C, et al., Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury. JCI Insight. 2024 Jun 24;9(12)

Mirc30 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir16-1, microRNA 16-1	miRNA gene	Chr14:61869329-61869421 (-)
Mir15a, microRNA 15a	miRNA gene	Chr14:61869476-61869559 (-)