Tg(ACTA1*D286G/EGFP)#Kjno
Transgene Detail

Summary

• Symbol: Tg(ACTA1*D286G/EGFP)#Kjno
• Name: transgene insertion, Kristen J Nowak
• MGI ID: MGI:5316719
• Synonyms: Tg(ACTA1.D286G-EGFP), Tg(ACTA1)^D286G-EGFP
• Transgene: Tg(ACTA1*D286G/EGFP)#Kjno Location: unknown
• Alliance: Tg(ACTA1*D286G/EGFP)#Kjno page

Transgene origin

• Strain of Origin: C57BL/6J x CBA/Ca

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(ACTA1*D286G/EGFP)#Kjno expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: This transgene expresses the human ACTA1 protein containing the D286G mutation fused at the C terminus to the coding sequence for EGFP under the control of the human skeletal muscle alpha-actin promoter (ACTA1) and the troponin-I slow upstream enhancer. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:182255)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182255 Ravenscroft G, et al., Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression. PLoS One. 2011;6(12):e28699
• All: 1 reference(s)