Tg(CMV-IGL@AL080)55Dcs
Transgene Detail

Summary

• Symbol: Tg(CMV-IGL@AL080)55Dcs
• Name: transgene insertion 55, David C Seldin
• MGI ID: MGI:5318684
• Synonyms: Tg(CMV-IGL6-AL080)55Dcs
• Transgene: Tg(CMV-IGL@AL080)55Dcs Location: unknown
• Alliance: Tg(CMV-IGL@AL080)55Dcs page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-IGL@AL080)55Dcs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	IGL (3535)

• Mutation details: This transgene expresses the human amyloidogenic immunoglobulin lambda 6 light chain and the bovine growth hormone polyadenylation sequence under the control of the cytomegalovirus (CMV) promoter. The lambda 6 light chain cDNA was generated by reverse transcription from RNA prepared from bone marrow collected from patient AL080 (GenBank sequence no. EF589388) who had rapidly progressive multiorgan amyloid light chain amyloidosis. (J:179082)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:179082 Ward JE, et al., Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15;118(25):6610-7
• All: 1 reference(s)