Tg(Ckm-CUGBP1)1039Coop
Transgene Detail

Summary

• Symbol: Tg(Ckm-CUGBP1)1039Coop
• Name: transgene insertion 1039, Thomas A Cooper
• MGI ID: MGI:5427873
• Synonyms: MCKCUG-BP1
• Transgene: Tg(Ckm-CUGBP1)1039Coop Location: unknown
• Alliance: Tg(Ckm-CUGBP1)1039Coop page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-CUGBP1)1039Coop expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CELF1 (10658)

  Celf1

  (MGI:1342295)

• Mutation details: A human CUGBP1, 'A' form, clone, containing an N-terminal FLAG epitope tag, was expressed in mice under the control of a mouse creatine kinase (MCK) promoter, enhancer, the untranslated exon 1, and intron 1 and bovine growth hormone 3' flanking genomic segment for proper mRNA 3' end formation. In addition to line 1039, linse 1032 and 1036 were also established. Western blot analysis showed that transgene expression is approximately 4-6 fold above endogenous levels. (J:99370)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99370 Ho TH, et al., Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet. 2005 Jun 1;14(11):1539-47
• All: 1 reference(s)