Tg(Disc1/EGFP)M19Sshe
Transgene Detail

Summary

• Symbol: Tg(Disc1/EGFP)M19Sshe
• Name: transgene insertion M19, Sanbing Shen
• MGI ID: MGI:5428215
• Synonyms: Disc1tr, Disc1tr-EGFP
• Transgene: Tg(Disc1/EGFP)M19Sshe Location: unknown
• Alliance: Tg(Disc1/EGFP)M19Sshe page

Transgene origin

• Strain of Origin: C57BL/6JCrl x CBA/CaCrl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Disc1/EGFP)M19Sshe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Disc1 (MGI:2447658)

• Mutation details: The mouse BAC RP23-236F19 was modified by inserting an EGFP inframe with Disc1 exon 8. Line M19, with 2 copies of the transgene, was generated. The insertion of EGFP truncates Disc1. (J:143557)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Disc1/EGFP)M19Sshe/0	involves: C57BL/6JCrl * CBA/CaCrl

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
behavior/neurological	√
abnormal latent inhibition of conditioning behavior	√
behavioral despair	√
decreased vocalization	√
cellular	√
abnormal axon extension	√
abnormal neuron proliferation	√
nervous system	√
abnormal axon extension	√
abnormal neuron proliferation	√
abnormal brain interneuron morphology	√
decreased brain size	√
enlarged lateral ventricles	√
dilated lateral ventricle	√
decreased corpus callosum size	√
thin cerebral cortex	√
abnormal neurite morphology	√
decreased neuron number	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

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disease model

expected model not found

Models:

Human Diseases	tg1
schizophrenia IDs schizophrenia       DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143557 Shen S, et al., Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci. 2008 Oct 22;28(43):10893-904
• All: 6 reference(s)