Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon
Transgene Detail

Summary

• Symbol: Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon
• Name: transgene insertion 632, Dimitris Kontoyiannis
• MGI ID: MGI:5429340
• Synonyms: Tg632, TgLrTtA-HAHuRL.632, Tg(LYS2-rtTA2S*M2,tetO-ELAVL1)632Dkon
• Transgene: Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon Location: unknown
• Alliance: Tg(LYZ-rtTA2S*M2,tetO-ELAVL1)632Dkon page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The first vector contains the human lysozyme promoter driving immune-specific expression of the tet-on effector transgene with the rtTA2S*M2 variant. A second vector contains the tetracycline responsive element driving the inducible expression of the human cDNA with an HA tag. Lines 632 and 662 were generated with five (Tg632) or two (Tg662) copies of the rtTA and comparable (six to eight) copies of the HA-ELAVL1 transgenes. (J:102638)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102638 Katsanou V, et al., HuR as a negative posttranscriptional modulator in inflammation. Mol Cell. 2005 Sep 16;19(6):777-89
• All: 2 reference(s)