Tg(Ly6e-MALT1)#Isg
Transgene Detail

Summary

• Symbol: Tg(Ly6e-MALT1)#Isg
• Name: transgene insertion, Isidro Sanchez-Garcia
• MGI ID: MGI:5432016
• Synonyms: Sca1-MALT1
• Transgene: Tg(Ly6e-MALT1)#Isg Location: unknown
• Alliance: Tg(Ly6e-MALT1)#Isg page

Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas

Show the 7 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ly6e-MALT1)#Isg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MALT1 (10892)

  Malt1

  (MGI:2445027)

• Mutation details: The mouse Ly6a promoter drives expression of the human MALT1 gene in the hematopoietic stem/progenitor cell compartment. Three lines (86A, 86B, 86C) were generated with 2 - 4 copies of the transgene inserted. RT-PCR and western blot analysis confirmed that transgene expression is restricted to Sca1+Lin- cells. (J:185590)

Schematic of the Tg(Ly6e-MALT1)#Isg transgene

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:185590 Vicente-Duenas C, et al., Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10534-9
• All: 1 reference(s)