Tg(CAG-Cfh*)#Mcp
Transgene Detail

Summary

• Symbol: Tg(CAG-Cfh*)#Mcp
• Name: transgene insertion, Matthew C Pickering
• MGI ID: MGI:5432032
• Synonyms: FHdelta16-20
• Transgene: Tg(CAG-Cfh*)#Mcp Location: unknown
• Alliance: Tg(CAG-Cfh*)#Mcp page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Cfh*)#Mcp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cfh (MGI:88385)

• Mutation details: A modified version of the CAGGS promoter drives expression of a mouse Cfh gene with a Cys937Stop mutation resulting in a truncated protein that lacks the terminal five SCR domains. The truncated protein is detected in the plasma at levels comparable to the wild-type protein. The truncated protein retained complement regulatory activity but showed impaired binding to heparin and human umbilical vein endothelial cells in vitro. (J:125860)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125860 Pickering MC, et al., Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 2007 Jun 11;204(6):1249-56
• All: 2 reference(s)