Tg(YAC128)54Hay
Transgene Detail

Summary

• Symbol: Tg(YAC128)54Hay
• Name: transgene insertion 54, Michael Hayden
• MGI ID: MGI:5432153
• Synonyms: HD54, YAC128
• Transgene: Tg(YAC128)54Hay Location: unknown
• Alliance: Tg(YAC128)54Hay page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 128 CAG repeat expansion. The resulting construct (YAC128) was used to generate transgenic mice. Founder line 54 had lower levels of protein expression compared to line 53 and 55. (J:84453)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105723 Graham RK, et al., Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiol Dis. 2006 Feb;21(2):444-55
• All: 3 reference(s)