Tg(Ins1-Kcnj11*)#Nich
Transgene Detail

Summary

• Symbol: Tg(Ins1-Kcnj11*)#Nich
• Name: transgene insertion, Colin G Nichols
• MGI ID: MGI:5432220
• Synonyms: Kir6.2[AAA]
• Transgene: Tg(Ins1-Kcnj11*)#Nich Location: unknown
• Alliance: Tg(Ins1-Kcnj11*)#Nich page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins1-Kcnj11*)#Nich expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kcnj11 (MGI:107501)

• Mutation details: The promoter for rat insulin 1 receptor was used to drive expression of mouse Kir6.2 in which the glycine-phenylalanine-glycine residues encoded by exons 156, 158, and 158 have been replaced by three alanines. Only one founder line was extablished. (J:61172)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:61172 Koster JC, et al., Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell. 2000 Mar 17;100(6):645-54
• All: 4 reference(s)