Tg(tetO-IGF1R)1Ramo
Transgene Detail

Summary

• Symbol: Tg(tetO-IGF1R)1Ramo
• Name: transgene insertion 1, Roger A Moorehead
• MGI ID: MGI:5432255
• Synonyms: TRE-IGF1R1
• Transgene: Tg(tetO-IGF1R)1Ramo Location: unknown
• Alliance: Tg(tetO-IGF1R)1Ramo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-IGF1R)1Ramo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1R (3480)

  Igf1r

  (MGI:96433)

• Mutation details: The tetracycline response element (TRE or tetO) was used to drive inducible expression of the full-length human IGF1R. In double transgenic mice also expressing the tetracycline transactivating or reverse transactivating element (tTA or rtTA), expression of IGF1R can be regulated by doxycycline administration or removal. Four lines were created. (J:121069)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121069 Jones RA, et al., Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007 Mar 8;26(11):1636-44
• All: 11 reference(s)