Tg(Thy1-SNCA)61Ema
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA)61Ema
• Name: transgene insertion 61, Eliezer Masliah
• MGI ID: MGI:5435401
• Synonyms: ASOTg, mThy-1-alpha-synuclein, mThy-1 tg
• Transgene: Tg(Thy1-SNCA)61Ema Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Thy1-SNCA)61Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SNCA)61Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: This transgene contains a human wild-type alpha synuclein fragment (nt 53-475) under the control of the mouse Thy1 promoter. Line 61 was generated. Transgene expression is seen throughout the brain, including the basal ganglia, thalamus, substantia nigra, and brainstem. (J:137490)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:137490 Rockenstein E, et al., Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res. 2002 Jun 1;68(5):568-78
• All: 62 reference(s)