Gm21970 Gene Detail

Summary

• Symbol
  Gm21970
• Name
  predicted gene 21970

• Feature Type
  protein coding gene
• IDs
  MGI:5439439
• Alliance
  gene page
• Transcription Start Sites
  13 TSS

Location &
Maps

• Sequence Map
  Chr16:91180749-91222722 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, Syntenic

Strain
Comparison

• SNPs within 2kb
  1031 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5439439	protein coding gene	Chr16:91180749-91222722 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023039	protein coding gene	Chr16:92394297-92425896 (+)
A/J	MGP_AJ_G0023007	protein coding gene	Chr16:88080063-88107626 (+)
AKR/J	MGP_AKRJ_G0022977	protein coding gene	Chr16:90735863-90767347 (+)
BALB/cJ	MGP_BALBcJ_G0023009	protein coding gene	Chr16:88599650-88635361 (+)
C3H/HeJ	MGP_C3HHeJ_G0022770	protein coding gene	Chr16:91300060-91329860 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023456	protein coding gene	Chr16:95388537-95420474 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020958	protein coding gene	Chr16:85780918-85808782 (+)
CAST/EiJ	MGP_CASTEiJ_G0022289	protein coding gene	Chr16:91865648-91893234 (+)
CBA/J	MGP_CBAJ_G0022739	protein coding gene	Chr16:99441054-99473518 (+)
DBA/2J	MGP_DBA2J_G0022873	protein coding gene	Chr16:87979631-88008623 (+)
FVB/NJ	MGP_FVBNJ_G0022847	protein coding gene	Chr16:87106901-87136306 (+)
LP/J	MGP_LPJ_G0022943	protein coding gene	Chr16:92103911-92135026 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022868	protein coding gene	Chr16:104015642-104046089 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023474	protein coding gene	Chr16:91253303-91283369 (+)
PWK/PhJ	MGP_PWKPhJ_G0022034	protein coding gene	Chr16:88157394-88185815 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021864	protein coding gene	Chr16:90809980-90837939 (+)
WSB/EiJ	MGP_WSBEiJ_G0022341	protein coding gene	Chr16:91494365-91524838 (+)

Homology

• Gene Tree
  Gm21970
  

Human Diseases

• References
  4 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  68 phenotype references
  

• All Mutations and Alleles
  8
• Spontaneous
  1
• Targeted
  6
• Genomic Mutations
  8 involving Gm21970
• Find Mice (IMSR)
  1 strains or lines available

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  25
• UniProt
  2

• Ensembl
  ENSMUSG00000093701 (Evidence)

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000093701	Ensembl Gene Model | MGI Sequence Detail	41974	C57BL/6J
transcript	ENSMUST00000160764	Ensembl | MGI Sequence Detail	2459	Not Applicable
polypeptide	ENSMUSP00000123997	Ensembl | MGI Sequence Detail	569	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR003961 Fibronectin type III
  IPR036116 Fibronectin type III superfamily
  IPR013783 Immunoglobulin-like fold
  IPR015373 Interferon/interleukin receptor domain
  IPR050650 Type II Cytokine and Tissue Factor Receptors

References

• Summaries
  All 71

  Diseases 4

  Phenotypes 68
• Earliest
  J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
• Latest
  J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

TSS for Gm21970:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139348	Chr16:91182888-91182927 (+)	2,159 bp
Tssr139349	Chr16:91184661-91184669 (+)	3,916 bp
Tssr139350	Chr16:91184906-91184930 (+)	4,169 bp
Tssr139351	Chr16:91184952-91184969 (+)	4,212 bp
Tssr139352	Chr16:91188631-91188657 (+)	7,895 bp
Tssr139353	Chr16:91188660-91188684 (+)	7,923 bp
Tssr139354	Chr16:91188699-91188728 (+)	7,965 bp
Tssr139355	Chr16:91190667-91190717 (+)	9,943 bp
Tssr139356	Chr16:91190735-91190755 (+)	9,996 bp
Tssr139357	Chr16:91194013-91194018 (+)	13,267 bp
Tssr139358	Chr16:91195901-91195910 (+)	15,157 bp
Tssr139359	Chr16:91196228-91196238 (+)	15,484 bp
Tssr139360	Chr16:91196862-91196904 (+)	16,134 bp