Tg(Vav1-JAK2*V617F)AZjz
Transgene Detail

Summary

• Symbol: Tg(Vav1-JAK2*V617F)AZjz
• Name: transgene insertion A, Zhizhuang Joe Zhao
• MGI ID: MGI:5441310
• Synonyms: JAK2^V617F, JAK2V617F tg
• Transgene: Tg(Vav1-JAK2*V617F)AZjz Location: unknown
• Alliance: Tg(Vav1-JAK2*V617F)AZjz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-JAK2*V617F)AZjz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  JAK2 (3717)

  Jak2	(MGI:96629)

• Mutation details: This transgene consists of the entire coding region of human JAK2 with the V617F mutation and the 3' noncoding region under the control of the Vav1 promoter. Line A is expressed in hematopoietic tissues, including the thymus, bone marrow, spleen, peripheral blood, and lymph nodes, but not in various nonhematopoietic tissues except for the lung. The gene copy number for line A is 13 +/- 1.4 based on real-time PCR. (J:135993)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:135993 Xing S, et al., Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 May 15;111(10):5109-17
• All: 12 reference(s)