Tg(Ins2-Tag*,-flpe)#Gne
Transgene Detail

Summary

• Symbol: Tg(Ins2-Tag*,-flpe)#Gne
• Name: transgene insertion, Genentech
• MGI ID: MGI:5441546
• Synonyms: RIP-TbetaAg
• Transgene: Tg(Ins2-Tag*,-flpe)#Gne Location: unknown
• Alliance: Tg(Ins2-Tag*,-flpe)#Gne page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Recombinase)
• Mutation: Insertion
• Tg(Ins2-Tag*,-flpe)#Gne expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgene consists of 2 co-injected constructs. The first construct contains the rat insulin promoter followed by an SV40 T antigen in which the two exons are interrupted by an FRT flanked beta-globin intron. The second construct contains he rat insulin promoter followed by a flpe gene. Recombination and expression of the transgene is seen in the pancreas. Absence of recombination in the liver and spleen was confirmed by PCR analysis. (J:187012)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (rat) Summary of all recombinase alleles driven by Ins2. Alliance rat Ins2 gene page

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:188693 Bagri A, et al., Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy. Clin Cancer Res. 2010 Aug 1;16(15):3887-900
• All: 3 reference(s)