Tg(H2-K^b-Jak2*V617F)2Shmd
Transgene Detail

Summary

• Symbol: Tg(H2-K^b-Jak2*V617F)2Shmd
• Name: transgene insertion 2, Kazuya Shimoda
• MGI ID: MGI:5444028
• Synonyms: JAK2 V617F
• Transgene: Tg(H2-K^b-Jak2*V617F)2Shmd Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(H2-K^b-Jak2*V617F)2Shmd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K^b-Jak2*V617F)2Shmd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Jak2 (MGI:96629)

• Mutation details: This transgene consists of murine Jak2 with a phenylalanine for valine substitution at residue 617 under the control of the H-2K^b promoter. The transgene integrated between Mef2a and Lrrc28 in this line. (J:130189)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130189 Shide K, et al., Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008 Jan;22(1):87-95
• All: 5 reference(s)