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Tg(Tlr7)1Boll
Transgene Detail
Summary
Symbol: Tg(Tlr7)1Boll
Name: transgene insertion 1, Silvia Bolland
MGI ID: MGI:5444399
Synonyms: TLR7.1 Tg
Transgene: Tg(Tlr7)1Boll  Location: unknown  
Alliance: Tg(Tlr7)1Boll page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tlr7)1Boll expresses 1 gene
 
Mutation detailsThe RP23-139P21 BAC construct that contains the Tlr7, Tlr8, and Tmsb4x genes, was replaced the first 83 kb with a neomycin cassette so that Tlr7 is be the only gene expressed. Six founder lines were produced with varying insert numbers and expression levels 4 to 16 fold greater than controls. This line has an 8- to 16-fold increase in expression. (J:127600)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127600 Deane JA, et al., Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity. 2007 Nov;27(5):801-10
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory