Tg(Fabp4-SREBF1)#Dajl
Transgene Detail

Summary

• Symbol: Tg(Fabp4-SREBF1)#Dajl
• Name: transgene insertion, David J Lloyd
• MGI ID: MGI:5446499
• Synonyms: aP2-nSrebp1c lipodystrophy Tg
• Transgene: Tg(Fabp4-SREBF1)#Dajl Location: unknown
• Alliance: Tg(Fabp4-SREBF1)#Dajl page

Lipodystrophy in Tg(Fabp4-SREBF1)#Dajl/0 males

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-SREBF1)#Dajl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

• Mutation details: A 5.4 Kb genomic fragment containing the mouse Fabp4 promoter/enhancer elements drives expression of a 1450 bp cDNA encompassing the mature human SREBF1 (residues 1-436). Transgene expression is detected in adipose tissues. (J:189510)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189510 Veniant MM, et al., FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One. 2012;7(7):e40164
• All: 1 reference(s)