Tg(Neurod2-Smo*A2)#Jols
Transgene Detail
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Symbol: |
Tg(Neurod2-Smo*A2)#Jols |
Name: |
transgene insertion, James M Olson |
MGI ID: |
MGI:5447065 |
Synonyms: |
ND2:SmoA2 |
Transgene: |
Tg(Neurod2-Smo*A2)#Jols Location: unknown
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Alliance: |
Tg(Neurod2-Smo*A2)#Jols page
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Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Neurod2-Smo*A2)#Jols expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Smo (MGI:108075) |
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Mutation details: The ND2:SmoA2 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA2 (S537N), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Four lines were generated (221, 222, 225 and 242). All lines exhibit a low level of transgene expression (4-, 1-, 3- and 2-fold, respectively for each line relative to wild-type levels). The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:93861)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800 |
All: |
4 reference(s) |
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