Tg(Col11a2-Npr2*)28Keoz
Transgene Detail

Summary

• Symbol: Tg(Col11a2-Npr2*)28Keoz
• Name: transgene insertion 28, Keiichi Ozono
• MGI ID: MGI:5448404
• Transgene: Tg(Col11a2-Npr2*)28Keoz Location: unknown
• Alliance: Tg(Col11a2-Npr2*)28Keoz page

Skeletal abnormalities in Tg(Col11a2-Npr2*)28Keoz/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col11a2-Npr2*)28Keoz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Npr2 (MGI:97372)

• Mutation details: The promoter and intronic enhancer of Col11a2 drives expression of a mutant version of Npr2 (p.Val883Met) in chondrocytes. Expression of Npr2 mRNA was increased 5.1 fold in costal cartilage. (J:189658)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189658 Miura K, et al., An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 2012;7(8):e42180
• All: 2 reference(s)