Tg(SOD1*G85R)#Roos
Transgene Detail

Summary

• Symbol: Tg(SOD1*G85R)#Roos
• Name: transgene insertion, Raymond Roos
• MGI ID: MGI:5448547
• Synonyms: G85R
• Transgene: Tg(SOD1*G85R)#Roos Location: unknown
• Alliance: Tg(SOD1*G85R)#Roos page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G85R)#Roos expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: This transgene consists of the human SOD1 carrying a glycine to arginine substitution at amino acid 85 (G86R), a mutation associated with familial amyotrophic lateral sclerosis. In addition, loxP sites were engineered to flank the G86R sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:147156)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:147156 Wang L, et al., Wild type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet. 2009 Feb 19;18(9):1642-51
• All: 6 reference(s)