Tg(CAG-Diap3)924Lesp
Transgene Detail

Summary

• Symbol: Tg(CAG-Diap3)924Lesp
• Name: transgene insertion 924, Marci Lesperance
• MGI ID: MGI:5462250
• Transgene: Tg(CAG-Diap3)924Lesp Location: unknown
• Alliance: Tg(CAG-Diap3)924Lesp page

The stereocilia of Tg(CAG-Diaph3)771Lesp/0 and Tg(CAG-Diap3)924Lesp/0 mice become progressively abnormal from 4 to 24 weeks of age

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Diap3)924Lesp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Diaph3 (MGI:1927222)

• Mutation details: A transgenic construct contains the mouse gene under the control of the CAG, CMV enhancer/chicken beta-actin, promoter. Founder line 924 was subsequently established. (J:193237)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:193237 Schoen CJ, et al., Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness. PLoS One. 2013;8(2):e56520
• All: 3 reference(s)