Rr21 Other Genome Feature Detail

Summary

• Symbol
  Rr21
• Name
  regulatory region 21
• Synonyms
  Myc-335

• Feature Type
  enhancer
• IDs
  MGI:5463399

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• chr15:61490136-61491875 (GRCm39) based on Rr21 deletion

• Genetic Map
  Chromosome 15, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  3 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  2
• Transposon induced
  1
• Genomic Mutations
  1 involving Rr21
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a deletion of this region are viable and fertile with no gross abnormalities. When on an intestinal polyp prone background homozygotes show resistance to polyp formation.

References

• Summaries
  All 4

  Phenotypes 3
• Earliest
  J:191217 Sur IK, et al., Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science. 2012 Dec 7;338(6112):1360-3
• Latest
  J:257088 Dave K, et al., Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth. Elife. 2017 Jun 6;6:e23382