Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
Transgene Detail
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Symbol: |
Tg(Itgax-HBEGF/OVA/EGFP)1Garbi |
Name: |
transgene insertion 1, Natalio Garbi |
MGI ID: |
MGI:5463655 |
Synonyms: |
CD11c.DOG, Tg(Itgax-DTR/OVA/EGFP)1Garbi, Tg(Itgax-DTR/OVA/EGFP)1Gjh |
Transgene: |
Tg(Itgax-HBEGF/OVA/EGFP)1Garbi Location: unknown
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Alliance: |
Tg(Itgax-HBEGF/OVA/EGFP)1Garbi page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Itgax-HBEGF/OVA/EGFP)1Garbi expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HBEGF (1839) |
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Mutation details: For generation of CD11c.DTR BAC transgenic mice, a fusion construct composed of the DNAs for the human DTR, ovalbumin fragment containing sequences encoding amino acids 140-386, and eGFP was generated and inserted at the start codon of the CD11c gene in the BAC RPCI-24-7812. The eGFP component of the fusion protein failed to give a fluorescence signal, whereas the ovalbumin protein was expressed in DC, resulting in extensive proliferation of ovalbumin-specific CD4 (OT-II) and CD8 (OT-I) cells after transfer into the CD11c.DOG mice.
(J:143470)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:143470 Hochweller K, et al., A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol. 2008 Oct;38(10):2776-83 |
All: |
30 reference(s) |
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