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Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
Transgene Detail
Summary
Symbol: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi
Name: transgene insertion 1, Natalio Garbi
MGI ID: MGI:5463655
Synonyms: CD11c.DOG, Tg(Itgax-DTR/OVA/EGFP)1Garbi, Tg(Itgax-DTR/OVA/EGFP)1Gjh
Transgene: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi  Location: unknown  
Alliance: Tg(Itgax-HBEGF/OVA/EGFP)1Garbi page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Itgax-HBEGF/OVA/EGFP)1Garbi expresses 1 gene
 
Mutation detailsFor generation of CD11c.DTR BAC transgenic mice, a fusion construct composed of the DNAs for the human DTR, ovalbumin fragment containing sequences encoding amino acids 140-386, and eGFP was generated and inserted at the start codon of the CD11c gene in the BAC RPCI-24-7812. The eGFP component of the fusion protein failed to give a fluorescence signal, whereas the ovalbumin protein was expressed in DC, resulting in extensive proliferation of ovalbumin-specific CD4 (OT-II) and CD8 (OT-I) cells after transfer into the CD11c.DOG mice. (J:143470)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:143470 Hochweller K, et al., A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol. 2008 Oct;38(10):2776-83
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory