Tg(Pcp2-ATXN2*127Q)#Plt
Transgene Detail

Summary

• Symbol: Tg(Pcp2-ATXN2*127Q)#Plt
• Name: transgene insertion, Stefan M Pulst
• MGI ID: MGI:5467321
• Synonyms: ATXN2^Q127
• Transgene: Tg(Pcp2-ATXN2*127Q)#Plt Location: unknown
• Alliance: Tg(Pcp2-ATXN2*127Q)#Plt page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-ATXN2*127Q)#Plt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN2 (6311)

  Atxn2

  (MGI:1277223)

• Mutation details: The Purkinje cell-specific mouse promoter drives expression of a modified human cDNA with an expansion of the trinucleotide repeat to encode 127 glutamine residues. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:191127)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:191127 Hansen ST, et al., Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2. Hum Mol Genet. 2013 Jan 15;22(2):271-83
• All: 9 reference(s)