Tg(Myh6-Cryab*R120G)708Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Cryab*R120G)708Rbns
• Name: transgene insertion 708, Jeffrey Robbins
• MGI ID: MGI:3795718
• Synonyms: CryAB^R120G, R120G-CryAB
• Transgene: Tg(Myh6-Cryab*R120G)708Rbns Location: unknown
• Alliance: Tg(Myh6-Cryab*R120G)708Rbns page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Cryab*R120G)708Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cryab (MGI:88516)	Transgene codes for a protein with a arginine to glycine mutation.

• Mutation details: This transgene expresses a mutant form of murine Cryab containing a missense mutation (R120G). This missense mutation acts in a dominant-negative fashion. In addition to transgenic line 708, lines 25 and 134 were also produced. The transgene copy number of this line is 1. (J:133093)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133093 Wang X, et al., Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res. 2001 Jul 6;89(1):84-91
• All: 22 reference(s)