Tg(CAG-Bmpr1a*,-lacZ)1Nobs
Transgene Detail

Summary

• Symbol: Tg(CAG-Bmpr1a*,-lacZ)1Nobs
• Name: transgene insertion 1, Noboru Suzuki
• MGI ID: MGI:5473821
• Synonyms: Tg(CAG-flox-dnBmpr1a-NLLacZ)1Nobs
• Transgene: Tg(CAG-Bmpr1a*,-lacZ)1Nobs Location: unknown
• Alliance: Tg(CAG-Bmpr1a*,-lacZ)1Nobs page

Transgene origin

• Strain of Origin: C57BL/6J x B6;129X1-Pcp2^tm1(cre)Nobs

Transgene description

• Transgene Type: Transgenic (Conditional ready, Dominant negative, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-Bmpr1a*,-lacZ)1Nobs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmpr1a (MGI:1338938)

• Mutation details: This transgene consists of the CAG promoter, loxP flanked stop codon, a 0.6 kb dominant-negative mouse Bmpr1a cDNA lacking the intracellular kinase domain (Y176STOP), a 0.5 kb internal ribosomal entry site (IRES), a 3.5 kb lacZ gene containing the nuclear localization signal, and a polyadenylation signal. Upon Cre-mediated excision of the Stop codon, the modified allele expresses the dominant negative Bmpr1a and lacZ in tissues where Cre is expressed. (J:192670)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:192670 Saito H, et al., Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism. Dis Model Mech. 2012 Nov;5(6):948-55
• All: 1 reference(s)