Tg(Tagln-SLC6A4)#Edd
Transgene Detail

Summary

• Symbol: Tg(Tagln-SLC6A4)#Edd
• Name: transgene insertion, Saadia Eddahibi
• MGI ID: MGI:5474459
• Synonyms: SM22-5-HTT⁺
• Transgene: Tg(Tagln-SLC6A4)#Edd Location: unknown
• Alliance: Tg(Tagln-SLC6A4)#Edd page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tagln-SLC6A4)#Edd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLC6A4 (6532)

  Slc6a4

  (MGI:96285)

• Mutation details: The murine taglin (Sm22) promoter (2191 bp starting 2126 bp before the start site) drives the expression of the human SLC6A4 (5-HTT) gene. RTQ-PCR and Western blot confirm expression in the lungs. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:144126)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144126 Guignabert C, et al., Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res. 2006 May 26;98(10):1323-30
• All: 6 reference(s)