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Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh
Transgene Detail
Summary
Symbol: Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh
Name: transgene insertion 2, Gunter J Hammerling
MGI ID: MGI:5476442
Synonyms: CD11c.LuciDTR
Transgene: Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh  Location: unknown  
Alliance: Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Recombinase)
Mutation:    Insertion
 
Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh expresses 1 gene
 
Tg(Itgax-EGFP,-cre,-HBEGF,-luc)2Gjh expression driven by 1 gene
 
Mutation detailsA cDNA construct encoding EGFP, cre recombinase, human diphtheria toxin receptor (DTR; HBEGF) and click beetle green 99 (CBG99) luciferase was generated, with coding sequences separated by self-cleaving 2A viral sequences. The presence of 2A sequences results in stoichiometric translation of the individual proteins. This construct was inserted at the ATG start codon of Itgax in the RPCI-24-7812 bacterial artificial chromosome by recombineering in bacterial cells. The modified BAC was linearized and injected into pronuclei of fertilized C57BL/6N oocytes and line 2 was established. (J:194800)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Itgax (mouse)
Summary of all recombinase alleles driven by Itgax.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:194800 Tittel AP, et al., Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods. 2012 Apr;9(4):385-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory