Tg(CMV-LITAF*W116G)#Lli
Transgene Detail

Summary

• Symbol: Tg(CMV-LITAF*W116G)#Lli
• Name: transgene insertion, Lian Li
• MGI ID: MGI:5478742
• Synonyms: SIMPLE W116G
• Transgene: Tg(CMV-LITAF*W116G)#Lli Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(CMV-LITAF*W116G)#Lli page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-LITAF*W116G)#Lli expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LITAF (9516)

  Litaf

  (MGI:1929512)

• Mutation details: The N-terminal hemagglutinin (HA)-tagged human LITAF with a W116G mutation is under the control of the human cytomegalovirus promoter. Three lines were made and this one is the highest expressing line. Immunoblot analysis of sciatic nerve and Schwann cell lysates confirmed expression and genome walking PCR and sequencing identified that the transgene inserted in a non-coding region on chromosome 14 between Thrb and Nr1d2. The pound symbol (#) is used when line is not specified. (J:194981)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194981 Lee SM, et al., Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet. 2013 May 1;22(9):1755-70
• All: 1 reference(s)