Rr26 Other Genome Feature Detail

Summary

• Symbol
  Rr26
• Name
  regulatory region 26
• Synonyms
  CRM4, EC1, GRE1

• Feature Type
  enhancer
• IDs
  MGI:5486165

Location &
Maps

• Sequence Map
  Chr2:113471188-113471625 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• chr2:113640843-113641280 (GRCm38)

• Genetic Map
  Chromosome 2, Syntenic

Strain
Comparison

• SNPs within 2kb
  128 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotypes from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Targeted
  1
• Genomic Mutations
  1 involving Rr26
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele for this Grem1 enhancer exhibit normal skeletal patterning.

References

• Summaries
  All 2

  Phenotypes 2
• Earliest
  J:207959 Li Q, et al., A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud. Development. 2014 May;141(9):1906-14
• Latest
  J:312378 Malkmus J, et al., Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity. Nat Commun. 2021 Sep 21;12(1):5557