Dp(5Gtf2i-Gtf2ird1)1Lro Cytogenetic Marker Detail

Summary

• Symbol
  Dp(5Gtf2i-Gtf2ird1)1Lro
• Name
  duplication, Chr 5, L Osborne 1
• Synonyms
  Dp(5Gtf2i-Gtf2ird)1Lro

• Feature Type
  chromosomal duplication
• IDs
  MGI:5490971

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 5, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  5 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous or heterozygous for this duplication exhibit increased ultrasonic vocalization during maternal-separation period.

References

• Summaries
  All 6

  Phenotypes 5
• Earliest
  J:222543 Proulx E, et al., Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. J Neurodev Disord. 2010 Jun;2(2):99-108
• Latest
  J:343071 Lopez-Tobon A, et al., GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders. Sci Adv. 2023 Dec;9(48):eadh2726