Tg(Thy1-APPSweLon)41Ema
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSweLon)41Ema
• Name: transgene insertion 41, Eliezer Masliah
• MGI ID: MGI:5491622
• Synonyms: APP41, mThy1-hAPP751, T41 APP, TASD41, Tg(Thy1-APP*K670N*M671L*V717I)41Ema, Tg(Thy1-APP*Swe*Lon)41Ema
• Transgene: Tg(Thy1-APPSweLon)41Ema Location: unknown
• Alliance: Tg(Thy1-APPSweLon)41Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSweLon)41Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish and London mutations.

• Mutation details: The murine Thy1 promoter drives expression of the hAPP751 cDNA containing the Swedish (K670N/M671L) and the London (V717I) mutations. Immunohistochemistry confirmed high expression of human APP in the neocortex and hippocampus and moderate expression in the thalamus, basal ganglia, and cerebellum. Three lines were made, 16, 11, and 41. Line 41 is the highest expressing line. (J:162842)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:162842 Rockenstein E, et al., Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42). J Neurosci Res. 2001 Nov 15;66(4):573-82
• All: 36 reference(s)