Tg(Myl1-SOD1*G93A)#Amu
Transgene Detail

Summary

• Symbol: Tg(Myl1-SOD1*G93A)#Amu
• Name: transgene insertion, Antonio Musaro
• MGI ID: MGI:5499110
• Synonyms: MLC/SOD1^G93A
• Transgene: Tg(Myl1-SOD1*G93A)#Amu Location: unknown
• Alliance: Tg(Myl1-SOD1*G93A)#Amu page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myl1-SOD1*G93A)#Amu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The human SOD1 cDNA with the G93A mutation is under the control of the regulatory elements of the rat Myl1 (MLC1f/3f) gene. Western and Northern blot analysis confirmed expression in skeletal muscle, predominantly in muscles enriched in fast fibers and reduced in slow muscles such as the soleus. (J:143747)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143747 Dobrowolny G, et al., Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab. 2008 Nov;8(5):425-36
• All: 6 reference(s)