Rr29 Other Genome Feature Detail

Summary

• Symbol
  Rr29
• Name
  regulatory region 29
• Synonyms
  MFCS1, ZRS, Zrs1

• Feature Type
  enhancer
• IDs
  MGI:5499537
  NCBI Gene: 105804842

Location &
Maps

• Sequence Map
  Chr5:29519879-29520665 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• Rr29 and Rr29 point mutations chr5:29519899-29520257 (GRCm39) J:316049 seq: chr5:29519879-29520665 (GRCm39)

• Genetic Map
  Chromosome 5,

Strain
Comparison

• SNPs within 2kb
  73 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  29 phenotypes from 10 alleles in 12 genetic backgrounds
  5 phenotypes from multigenic genotypes
  2 images
  25 phenotype references
  

• All Mutations and Alleles
  28
• Chemically induced (ENU)
  8
• Endonuclease-mediated
  12
• Spontaneous
  1
• Targeted
  7
• Genomic Mutations
  1 involving Rr29
• Find Mice (IMSR)
  2 strains or lines available

Mice lacking the MFCS1 or ZRS enhancer of Shh exhibit oligodactyly.

Sequences &
Gene Models

• All Sequences
  3
• RefSeq
  1

• NCBI Gene
  105804842

Representative Sequences			Length	Strain/Species
genomic	105804842	NCBI Gene Model | MGI Sequence Detail	1366	C57BL/6J

Other
Accession IDs

MGI:3028525

References

• Summaries
  All 36

  Phenotypes 25
• Earliest
  J:31035 Knudsen TB, et al., The role of morphogenetic cell death during abnormal limb-bud outgrowth in mice heterozygous for the dominant mutation Hemimelia-extra toe (Hmx). J Embryol Exp Morphol. 1981 Oct;65 Suppl:289-307
• Latest
  J:347410 Chen Z, et al., Increased enhancer-promoter interactions during developmental enhancer activation in mammals. Nat Genet. 2024 Apr;56(4):675-685