Del(2Hoxd1-Hoxd9)63Ddu Cytogenetic Marker Detail

Summary

• Symbol
  Del(2Hoxd1-Hoxd9)63Ddu
• Name
  deletion, Chr 2, Denis Duboule 63

• Feature Type
  chromosomal deletion
• IDs
  MGI:5508533

Location &
Maps

• Sequence Map
  Chr2:74528107-74595486 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice heterozygous for this deletion exhibit atypical female courtship behavior with female mice aggressively chasing males and biting their genitals.

References

• Summaries
  All 4

  Phenotypes 3
• Earliest
  J:199759 Zakany J, et al., A genetic basis for altered sexual behavior in mutant female mice. Curr Biol. 2012 Sep 25;22(18):1676-80
• Latest
  J:259687 Zakany J, et al., Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo. BMC Res Notes. 2018 Mar 27;11(1):193